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What is Wellbutrin SR?


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Wellbutrin is an antidepressant medication, and the 'SR' means sustained release. Its generic name is Bupropion Hydrochloride SR, used for the treatment of seasonal depressive (affective) disorder and major depressive disorder. Though not approved for use by the FDA, some brands of Bupropion Hydrochloride are used for the treatment of insomnia. The drug may also be used for purposes other than those mentioned here. 

The Action of Wellbutrin SR on the Brain 

There are several chemical messengers in the brain called neurotransmitters. Examples include dopamine, serotonin, and norepinephrine. These neurotransmitters are important for managing one's mood, fear, happiness, sleep, and overall mental well-being. Hence, the physiological balance in the levels of these neurotransmitters is vital for mental health. 

Wellbutrin SR works by balancing the levels of neurotransmitters to ensure overall mental health. 

How to Use Wellbutrin SR

You should take Wellbutrin SR as directed by a health professional. The drug is consumed orally and with a meal or none. However, it should not be crushed or chewed but swallowed whole. 


When commencing the first treatment with Wellbutrin SR, you would be required to take smaller doses in the morning. However, as you progress with your treatment the dosage may increase and the schedule will include mornings and evenings. 


Do not stop using the drug abruptly even if you begin to feel better or change your dose without your doctor's knowledge. This could predispose you to withdrawal syndromes or severe seizures. 

Wellbutrin SR Dosing Information 

The dose usually takes the form of an initial, maintenance, and maximum dose. Also, there are dosage modifications that a doctor should determine for patients with liver and or kidney impairment. Although the dosage your doctor will prescribe is based on your condition and how beneficial the drug will be for you, a general guideline is described below.


For the treatment of depression in adults, the initial dose is 150 mg taken in the morning. If necessary, it can be increased after 3 days to a maintenance dose of 150 mg two times (morning and evening) per day. However, you should not take more than 400 mg per 24 hours. Also, you should not take more than 200 mg in a single dose. 


For adults with seasonal affective disorder, the initial dose is 150 mg once in the morning for 6 days. If necessary, it can be increased to 300 mg once in the morning on the 7th day. The maximum dose for a day is 300 mg. 

Benefits of Consuming Wellbutrin SR

People who use the drug tend to benefit from the following:

  • Reduced chances of developing withdrawal symptoms
  • Relieves seasonal depressive disorder 
  • Helps in suppressing the symptoms encountered by people suffering from major depressive disorders 
  • It can be safely stacked with other drugs for maximum relief 


Before taking this drug, kindly inform your physician if you react negatively to Bupropion Hydrochloride. Also, inform your doctor if have any history of:

  • Hypertension 
  • Diabetes
  • Kidney disorders
  • Liver diseases 
  • Seizures
  • Controlled substance/alcohol abuse 


Due to safety concerns, Wellbutrin SR should not be given to people who are less than 18 years of age. It is also pertinent that you only take this drug after your doctor has assessed that the benefits of consuming it outweigh the risks. This is especially important if you are pregnant. Again, Wellbutrin SR can pass into the breast milk and can make a nursing baby uncomfortable. 

Missed Dose and Overdose

If you miss a dose, skip it. You can take it as your next dose at the regular time. In case of overdose or accidental poisoning, call 911 or the poison control center in your area. Be patient while taking the drug because it may take 7-14 days for you to start feeling better. Also, Wellbutrin SR is not known to cause weight gain. However, people react differently to drugs.

Side Effects

The common side effects associated with Wellbutrin SR are:

  • Sore throat
  • Headache
  • Itching
  • Dry mouth
  • Constipation 
  • Loss of appetite
  • Vomiting
  • Nausea
  • Weight changes
  • Ringing sensation in the ears
  • Tremor
  • Sleep troubles
  • Increased sweating 


Other adverse effects include:

  • Memory loss
  • Irregular heartbeat
  • Confusion
  • Blurry vision
  • Anxiety
  • Allergic reactions


Wellbutrin SR interacts with over 400 drugs, 8 disease conditions, and alcohol. Some of the drug interactions are listed below:

  • Other antidepressants like Fluoxetine, Zoloft, and Lexapro
  • Monoamine oxidase inhibitors like linezolid and procarbazine
  • Prednisone
  • Lisinopril
  • Abilify
  • Tramadol 
  • Dextroamphetamine 
  • Omeprazole
  • Metformin
  • Ambien
  • Cetirizine
  • Ibuprofen and
  • Trazodone 

The disease conditions which interact with these drugs are:

  • Psychosis
  • Liver disorders
  • Glaucoma (angle-closure type)
  • Suicidality
  • Manic episodes
  • Kidney dysfunction
  • Seizure disorders and
  • Weight loss 

It is generally recommended by experts that consumption of alcohol while on Bupropion therapy should be discontinued or minimized. This is to prevent the risk of developing serious side effects.

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